sFLT1, PlGF, the sFLT1/PlGF Ratio and Their Association with Pre-eclampsia in Twin Pregnancies—A Review of the Literature

Twin pregnancies demonstrate a 2–3-fold higher chance of developing PE compared to singletons, and recent evidence has demonstrated that the sFLT1/PIGF ratio is strongly associated with PE, adverse pregnancy outcomes, as well imminent deliveries due complications. The primary objective this systematic review was summarise available data on levels sFLT1, PlGF their ratios in twin investigate association development outcomes timing delivery. A search Ovid Embase, Web Science, Science Direct, PubMed, Medline, Google Scholar CINAHL carried out. sFLT1 appeared twins singleton pregnancies, especially third trimester, while up until values showing no difference or being even lower than singletons thereafter. been reported be an independent marker related pre-eclampsia mean time delivery inverse manner. Further research required order establish optimal cut-off stratify risk pregnancies.